Drug General Information (ID: DDI72TWO8G)
Drug Name			Coagulation factor VIIa Recombinant Human		Drug Info		Factor IX Complex (Human)		Drug Info
Drug Type		Protein/peptide				Protein/peptide
Therapeutic Class		Coagulation Modifiers				Coagulation Modifiers

Mechanism of Coagulation factor VIIa Recombinant Human-Factor IX Complex (Human) Interaction (Severity Level: Moderate)
Additive thrombogenic effects Click to Show/Hide Mechanism Graph
Drug Name		Coagulation factor VIIa Recombinant Human				Factor IX Complex (Human)
Mechanism		Thrombogenic effects				Thrombogenic effects
Key Mechanism Factor 1
		Factor Name		Thrombogenic effects
		Factor Description		Drug-induced thrombosis disrupts the balance between thrombogenic factors and protective mechanisms and tends to produce thrombosis. Drug-induced thrombosis usually causes venous thrombotic events, and arterial thrombotic events are also noted as a result of drug administration
Mechanism Description		Additive thrombogenic effects by the combination of Coagulation factor VIIa Recombinant Human and Factor IX Complex (Human)

Recommended Action
Management		Product labeling for coagulation factor VIIa recommends that simultaneous use of activated or nonactivated prothrombin complex concentrates be avoided.

References
1	Product Information. NovoSeven (coagulation factor VIIa) Novo Nordisk Pharmaceuticals, Princeton, NJ.