Drug General Information (ID: DDI68Z3JE0)
Drug Name			Insulin human (inhalation, rapid acting)		Drug Info		Umeclidinium		Drug Info
Drug Type		Hormones				Small molecule
Therapeutic Class		Insulin/Antidiabetic Agents				Bronchodilators
Structure

Mechanism of Insulin human (inhalation, rapid acting)-Umeclidinium Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Insulin human (inhalation, rapid acting)				Umeclidinium
Mechanism		Inhaled human insulin				Alter the absorption of inhaled human insulin
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Insulin human (inhalation, rapid acting) caused by Umeclidinium

Recommended Action
Management		Consistent timing of dosing of other inhaled products relative to inhaled human insulin administration is recommended. Blood glucose should be monitored closely, and the insulin dose adjusted accordingly.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Jerntorp P, Almer LO "Chlorpropamide-alcohol flushing in relation to macroangiopathy and peripheral neuropathy in non-insulin dependent diabetes." Acta Med Scand 656 (1981): 33-6. [PMID: 6953748]
3	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]