Drug General Information (ID: DDI68IWFXD)
Drug Name			Ranitidine (bismuth citrate)		Drug Info		Dasatinib		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiulcer Agents				Antineoplastics
Structure

Mechanism of Ranitidine (bismuth citrate)-Dasatinib Interaction (Severity Level: Major)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Ranitidine (bismuth citrate)				Dasatinib
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Dasatinib due to altered gastric pH caused by Ranitidine (bismuth citrate)

Recommended Action
Management		Concomitant use of dasatinib with H2-receptor antagonists or proton pump inhibitors is not recommended. If gastric acidity management is necessary, antacids should be considered in place of these agents. However, patients treated with dasatinib should avoid taking antacids or oral medications that contain antacids (e.g., didanosine buffered tablets or pediatric oral solution) for at least two hours before and two hours after administration of dasatinib.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.