Drug General Information (ID: DDI681TVCE)
Drug Name			Insulin human (inhalation, rapid acting)		Drug Info		Phentolamine		Drug Info
Drug Type		Hormones				Small molecule
Therapeutic Class		Insulin/Antidiabetic Agents				Antihypertensive Agents
Structure

Mechanism of Insulin human (inhalation, rapid acting)-Phentolamine Interaction (Severity Level: Minor)
Increased risk of hypoglycemia Click to Show/Hide Mechanism Graph
Drug Name		Insulin human (inhalation, rapid acting)				Phentolamine
Mechanism		Insulin				Hypoglycemic effects Increase the endogenous secretion of insulin
Key Mechanism Factor 1
		Factor Name		Hypoglycemia
		Factor Description		Hypoglycemia is a condition in which your blood sugar (glucose) level is below the standard range. It causes irregular or rapid heartbeat, pale skin, numbness of the lips, tongue or cheeks, and sweating.
Mechanism Description		Increased risk of hypoglycemia by the combination of Insulin human (inhalation, rapid acting) and Phentolamine

References
1	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
2	Persson I, Larsen L "Serum insulin concentration after alpha-adrenergic blockade and secretin in diabetics." Acta Endocrinol (Copenh) 71 (1972): 331-7
3	Linde J, Deckert T "Increase of insulin concentration in maturity-onset diabetics by phentolamine (Regitine) infusion." Horm Metab Res 5 (1973): 391-5