Drug General Information (ID: DDI65HS4VU)
Drug Name			Etanercept		Drug Info		Vedolizumab		Drug Info
Drug Type		Monoclonal antibody				Monoclonal antibody
Therapeutic Class		Antirheumatics				Selective Immunosuppressants

Mechanism of Etanercept-Vedolizumab Interaction (Severity Level: Major)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Etanercept				Vedolizumab
Mechanism		Immunosuppressive effects				Immunosuppressive effects
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Etanercept and Vedolizumab

Recommended Action
Management		The safety and efficacy of vedolizumab in combination with TNF blockers have not been established. Concomitant use should be avoided.

References
1	Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
2	Product Information. Enbrel (etanercept). Wyeth-Ayerst Laboratories, Philadelphia, PA.
3	Product Information. Entyvio (vedolizumab). Takeda Pharmaceuticals America, Lincolnshire, IL.
4	Product Information. Humira (adalimumab). Abbott Pharmaceutical, Abbott Park, IL.
5	Product Information. Remicade (infliximab). Centocor Inc, Malvern, PA.
6	Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.
7	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Drug labels for the Tumor Necrosis Factor-alpha (TNFa) blockers now include warnings about infection with Legionella and Listeria bacteria. ".