Drug General Information (ID: DDI64SKLZI)
Drug Name			Liothyronine		Drug Info		Ertugliflozin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Hormone Replacement Agents				Antidiabetic Agents
Structure

Mechanism of Liothyronine-Ertugliflozin Interaction (Severity Level: Moderate)
Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Drug Name		Liothyronine				Ertugliflozin
Mechanism 1		Hyperglycemia				Antidiabetic agent
Key Mechanism Factor 1
		Factor Name		Antihypertensive agents
		Factor Description		The hypotensive effect of antihypertensive agents may be reduced, leading to higher blood pressure, increased blood pressure fluctuations, and possible cardiovascular damage.
Mechanism Description		Antagonize the effect of Ertugliflozin when combined with Liothyronine
Mechanism 2		Hyperglycemic effects				Antidiabetic agent
Key Mechanism Factor 2
		Factor Name		Antihypertensive agents
		Factor Description		The hypotensive effect of antihypertensive agents may be reduced, leading to higher blood pressure, increased blood pressure fluctuations, and possible cardiovascular damage.
Mechanism Description		Antagonize the effect of Ertugliflozin when combined with Liothyronine

Recommended Action
Management		Close clinical monitoring of glycemic control is recommended following initiation or discontinuation of these drugs, and the dosages of concomitant antidiabetic agents adjusted as necessary. Patients should be advised to notify their physician if their blood glucose is consistently high or if they experience symptoms of severe hyperglycemia such as excessive thirst and increases in the volume or frequency of urination.

References
1	Jori A, Carrara MC "On the mechanism of the hyperglycaemic effect of chlorpromazine." J Pharm Pharmacol 18 (1966): 623-4. [PMID: 4381950]
2	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
3	Product Information. Thorazine (chlorpromazine). SmithKline Beecham, Philadelphia, PA.