Details of Drug-Drug Interaction
| Drug General Information (ID: DDI62TXIQF) | |||||||||
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| Drug Name | Interferon alfa-2a, Recombinant | Drug Info | Bupropion | Drug Info | |||||
| Drug Type | Interferons | Small molecule | |||||||
| Therapeutic Class | Interferons | Antidepressants | |||||||
| Mechanism of Interferon alfa-2a, Recombinant-Bupropion Interaction (Severity Level: Major) | |||||||||
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| Increased risk of lowers seizure threshold Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Interferon alfa-2a, Recombinant | Bupropion | |||||||
| Mechanism | Lower seizure threshold | Lower seizure threshold | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Lowers seizure threshold | ||||||||
| Factor Description | The combination of medications that lower the seizure threshold is a factor that makes people with epilepsy more likely to have seizures. A seizure is a sudden, uncontrolled electrical disturbance in the brain that can cause changes in your behavior, movements or sensations, and level of consciousness. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Extreme caution is advised if bupropion is administered with any substance that can reduce the seizure threshold, particularly in the elderly and in patients with a history of seizures or other risk factors for seizures (e.g., head trauma brain tumor severe hepatic cirrhosis metabolic disorders CNS infections excessive use of alcohol or sedatives addiction to opiates, cocaine, or stimulants diabetes treated with oral hypoglycemic agents or insulin). Bupropion as well as concomitant medications should be initiated at the lower end of the dosage range and titrated gradually as needed and as tolerated. The maximum recommended dosage for the specific bupropion formulation should not be exceeded. Bupropion should be discontinued and not restarted in patients who experience a seizure during treatment. | ||||||||