Drug General Information (ID: DDI62NJWKU)
Drug Name			Enflurane		Drug Info		Amikacin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anesthetics				Antibiotics
Structure

Mechanism of Enflurane-Amikacin Interaction (Severity Level: Moderate)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Enflurane				Amikacin
Mechanism		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Enflurane and Amikacin

Recommended Action
Management		Monitoring of renal function is recommended.

References
1	Motuz DJ, Watson WA, Barlow JC, et al "The increase in urinary alanine aminopeptidase excretion associated with enflurane anesthesia is increased further by aminoglycosides." Anesth Analg 67 (1988): 770-4. [PMID: 2899408]