Drug General Information (ID: DDI5U4L80M)
Drug Name			Valproic acid		Drug Info		Lanthanum carbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticonvulsants				Phosphate Binders
Structure

Mechanism of Valproic acid-Lanthanum carbonate Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Valproic acid				Lanthanum carbonate
Mechanism		Binds to anion exchange resin/polymer				Anion exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Lanthanum carbonate due to formation of complexes caused by Valproic acid

Recommended Action
Management		To minimize the potential for interaction, drugs that are known to interact with antacids (e.g., ACE inhibitors, beta blockers, bisphosphonates, coumarin derivatives, digitalis glycosides, fluoroquinolones, iron, phenytoin, rifampin, tetracyclines, thyroid preparations, valproic acid) should not be taken within 2 hours of administration of lanthanum carbonate according to the product labeling.

References
1	Canadian Pharmacists Association.
2	Cerner Multum, Inc. "Australian Product Information.".
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	Product Information. Fosrenol (lanthanum carbonate). Shire US Inc, Florence, KY.
5	Product Information. Nuzyra (omadacycline). Paratek Pharmaceuticals, Inc., Boston, MA.
6	Product Information. Seysara (sarecycline). Allergan Inc, Irvine, CA.