Drug General Information (ID: DDI5T8JEU0)
Drug Name			Miglitol		Drug Info		Activated charcoal		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidiabetic Agents				Antidotes
Structure

Mechanism of Miglitol-Activated charcoal Interaction (Severity Level: Moderate)
Adsorption Click to Show/Hide Mechanism Graph
Drug Name		Miglitol				Activated charcoal
Mechanism		Adsorbed by activated charcoal				Activated charcoal
Key Mechanism Factor 1
		Factor Name		Adsorption
		Factor Description		Adsorption is a direct drug interaction, usually through adsorption on its surface, resulting in reduced absorption of concomitantly administered drugs in the gastrointestinal tract.
Mechanism Description		Decreased absorption of Miglitol due to adsorption of Activated charcoal

Recommended Action
Management		Alpha-glucosidase inhibitors should not be administered simultaneously with intestinal adsorbents or preparations containing carbohydrate-splitting digestive enzymes. The optimal dosing interval between these agents has not been established. Postprandial blood glucose and glycosylated hemoglobin (HbA1c) should be monitored to ensure adequate therapeutic response to alpha-glucosidase inhibitor therapy.

References
1	Product Information. Glyset (miglitol). Bayer, West Haven, CT.
2	Product Information. Precose (acarbose). Bayer, West Haven, CT.