Drug General Information (ID: DDI5RSQIXA)
Drug Name			Mecamylamine		Drug Info		Nefazodone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Antidepressants
Structure

Mechanism of Mecamylamine-Nefazodone Interaction (Severity Level: Moderate)
Additive hypotensive effects Click to Show/Hide Mechanism Graph
Drug Name		Mecamylamine				Nefazodone
Mechanism		Hypotensive effects Neuronal acetylcholine receptor  Antagonist				Potentiate the hypotensive effect of antihypertensive agents
Key Mechanism Factor 1
		Factor Name		Neuronal acetylcholine receptor				Structure Sequence
		Protein Family		Ligand-gated ion channel (TC 1.A.9) family
		Protein Function		After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Mecamylamine and Nefazodone

Recommended Action
Management		Caution and close monitoring for altered efficacy and safety are recommended if patients receive nefazodone with agents that can produce significant hypotension such as antihypertensive agents or vasodilators. Patients should be made aware of the possible side effects (e.g., dizziness, lightheadedness, orthostasis) and be cautioned about driving, operating machinery, or performing other hazardous tasks.

References
1	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
2	Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
3	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]