Drug General Information (ID: DDI5QVA192)
Drug Name			Naltrexone		Drug Info		Bremelanotide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidotes				Melanocortin Receptor Agonists
Structure

Mechanism of Naltrexone-Bremelanotide Interaction (Severity Level: Major)
Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Drug Name		Naltrexone				Bremelanotide
Mechanism		Absorption affected by delayed gastric emptying				Delayed gastric emptying
Key Mechanism Factor 1
		Factor Name		Gastrointestinal Motility
		Factor Description		Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
Mechanism Description		Altered absorption of Naltrexone due to GI dynamics variation caused by Bremelanotide

Recommended Action
Management		The prescribing information for bremelanotide recommends avoiding concomitant use with orally administered naltrexone-containing products that are intended for the treatment of alcohol or opioid addiction. When naltrexone is used for other indications, monitor for potentially reduced therapeutic efficacy when coadministered with bremelanotide.

References
1	Product Information. Vyleesi (bremelanotide). AMAG Pharmaceuticals Inc, Lexington, MA.