Drug General Information (ID: DDI5OVXQI4)
Drug Name			Nitroprusside		Drug Info		Tetracosactide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Diagnostic Agents
Structure

Mechanism of Nitroprusside-Tetracosactide Interaction (Severity Level: Moderate)
Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Drug Name		Nitroprusside				Tetracosactide
Mechanism		Antihypertensive agent Guanylate cyclase  Agonist				Hypertensive effects Induction of sodium and fluid retention
Key Mechanism Factor 1
		Factor Name		Guanylate cyclase soluble				Structure Sequence
		Protein Family		Adenylyl cyclase class-4/guanylyl cyclase family
		Protein Function		There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms. Activated by nitric oxide in the presence of magnesium or manganese ions.     Click to Show/Hide
Mechanism Description		Antagonize the effect of Nitroprusside when combined with Tetracosactide

Recommended Action
Management		Patients on prolonged (i.e., longer than about a week) or high-dose corticosteroid therapy should have blood pressure, electrolyte levels, and body weight monitored regularly, and be observed for the development of edema and congestive heart failure. The dosages of antihypertensive medications may require adjustment.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Multum Information Services, Inc. Expert Review Panel.