Details of Drug-Drug Interaction
| Drug General Information (ID: DDI5K26OHF) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Ampicillin | Drug Info | Dexlansoprazole | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antibiotics | Proton Pump Inhibitors | |||||||
| Structure | |||||||||
| Mechanism of Ampicillin-Dexlansoprazole Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Altered gastric pH Click to Show/Hide Mechanism Graph | |||||||||
 |
|||||||||
| Drug Name | Ampicillin | Dexlansoprazole | |||||||
| Mechanism | Gastric pH sensitive | Gastric alkalinizer | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Gastric pH | ||||||||
| Factor Description | The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs. | ||||||||
| Mechanism Description |
|
||||||||
| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | If lansoprazole therapy is required, consideration should be given to alternative antimicrobial agents. | ||||||||
| References | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Product Information. Kapidex (dexlansoprazole). Takeda Pharmaceuticals America, Lincolnshire, IL. | ||||||||||||||||||
| 2 | Product Information. Prevacid (lansoprazole). TAP Pharmaceuticals Inc, Deerfield, IL. | ||||||||||||||||||