Details of Drug-Drug Interaction
| Drug General Information (ID: DDI5IXB4NW) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Nilotinib | Drug Info | Dexlansoprazole | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antineoplastics | Proton Pump Inhibitors | |||||||
| Structure | |||||||||
| Mechanism of Nilotinib-Dexlansoprazole Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Increased risk of hypomagnesemia Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Nilotinib | Dexlansoprazole | |||||||
| Mechanism | Hypomagnesemia | Hypomagnesemia | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Hypomagnesemia | ||||||||
| Factor Description | Hypomagnesemia is a condition that occurs when you have too much magnesium in your body. Symptoms of hypomagnesemia include: nausea, vomiting, neurological damage, abnormally low blood pressure (hypotension), flushing, and headaches. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | The concomitant use of proton pump inhibitors should generally be avoided during therapy with nilotinib. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ. | ||||||||||||||||||