Drug General Information (ID: DDI5IWYDSE)
Drug Name			Streptomycin		Drug Info		Plazomicin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Aminoglycosides//Antibiotics
Structure

Mechanism of Streptomycin-Plazomicin Interaction (Severity Level: Moderate)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Streptomycin				Plazomicin
Mechanism 1		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Streptomycin and Plazomicin
Increased risk of ototoxicity Click to Show/Hide Mechanism Graph
Drug Name		Streptomycin				Plazomicin
Mechanism 2		Ototoxicity				Ototoxicity
Key Mechanism Factor 2
		Factor Name		Ototoxicity
		Factor Description		Ototoxicity is the damage to the organs of hearing and/or balance following exposure to drugs or chemicals that affect the inner ear. Ototoxic drugs can impair hearing, balance, or both.
Mechanism Description		Increased risk of ototoxicity by the combination of Streptomycin and Plazomicin

Recommended Action
Management		The use of more than one aminoglycoside should be avoided. Patients receiving aminoglycosides should be closely monitored for development of toxicity, including renal function tests and serial, vestibular, and audiometric tests. Ototoxicity may be permanent and may not be apparent until long after therapy has been discontinued. The onset of auditory toxicity may be asymptomatic or may manifest with early symptoms such as feelings of fullness in the ear, high tone hearing loss, or tinnitus. Signs of vestibulotoxicity include ataxia, tinnitus, and vertigo.

References
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11	Product Information. Mycifradin (neomycin). Emerson Laboratories, Texarkana, TX.
12	Product Information. Nebcin (tobramycin). Lilly, Eli and Company, Indianapolis, IN.
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