Drug General Information (ID: DDI5HLVCD4)
Drug Name			Tolcapone		Drug Info		Desipramine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiparkinson Agents				Antidepressants
Structure

Mechanism of Tolcapone-Desipramine Interaction (Severity Level: Moderate)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Tolcapone				Desipramine
Mechanism		Tolcapone				Increased incidence of adverse reactions may occur when taken concurrently with tolcapone
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Tolcapone and Desipramine

Recommended Action
Management		The manufacturer recommends caution if desipramine is given to patients receiving tolcapone and levodopa/carbidopa.

References
1	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
2	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
3	Product Information. Tasmar (tolcapone). Valeant Pharmaceuticals, Costa Mesa, CA.