Drug General Information (ID: DDI50FV461)
Drug Name			Propranolol		Drug Info		Maprotiline		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antianxiety Agents				Antidepressants
Structure

Mechanism of Propranolol-Maprotiline Interaction (Severity Level: Minor)
Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Propranolol				Maprotiline
Mechanism		Decrease the metabolism of maprotiline				Maprotiline
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased metabolism of Maprotiline caused by Propranolol

References
1	Saiz-Ruiz J, Moral L "Delirium induced by association of propranolol." J Clin Psychopharmacol 8 (1988): 77-8. [PMID: 3351011]
2	Tollefson G, Lesar T "Effect of propranolol on maprotiline clearance." Am J Psychiatry 141 (1984): 148-9. [PMID: 6691445]