Drug General Information (ID: DDI4X86ASR)
Drug Name			Apomorphine		Drug Info		Metoclopramide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Dopaminergic Antiparkinsonism Agents				Antiemetics
Structure

Mechanism of Apomorphine-Metoclopramide Interaction (Severity Level: Moderate)
Antagonize the effect of dopaminergic agents Click to Show/Hide Mechanism Graph
Drug Name		Apomorphine				Metoclopramide
Mechanism		Dopaminergic effects Dopamine receptor  Agonist				Antidopaminergic effects Dopamine receptor  Antagonist
Key Mechanism Factor 1
		Factor Name		Dopamine receptor				Structure Sequence
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.     Click to Show/Hide
Mechanism Description		Antagonize the effect of Apomorphine when combined with Metoclopramide

Recommended Action
Management		The use of apomorphine in combination with dopamine antagonists should generally be avoided unless the potential benefits outweigh the risks. Monitoring for altered efficacy of apomorphine and increased side effects such as sedation or hypotension is recommended if concomitant use is required. Patients should be advised to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope. Also, they should avoid activities requiring mental alertness until they know how these agents affect them. Patients who experience increased episodes of falling asleep during normal daily activities should avoid driving and other potentially hazardous activities until they have been evaluated by their physician.

References
1	Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.