Drug General Information (ID: DDI4UB9AX6)
Drug Name			Methylphenidate		Drug Info		Sevoflurane		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cns Stimulants				Anesthetics
Structure

Mechanism of Methylphenidate-Sevoflurane Interaction (Severity Level: Moderate)
Additive hypertensive effects Click to Show/Hide Mechanism Graph
Drug Name		Methylphenidate				Sevoflurane
Mechanism		Hypertensive effects				Hypertensive effects
Key Mechanism Factor 1
		Factor Name		Hypertensive effects
		Factor Description		Hypertension is defined as a blood pressure reading above a prescribed limit (130/90 mmHg). Most people with hypertension have no signs or symptoms; others may experience: severe headache, shortness of breath, nosebleeds, severe anxiety, and feeling a tingling sensation in the neck or head.
Mechanism Description		Additive hypertensive effects by the combination of Methylphenidate and Sevoflurane

Recommended Action
Management		When surgery is planned, it is recommended that methylphenidate should not be taken on the day of surgery.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Metadate CD Capsules (methylphenidate) Celltech Pharmaceuticals, Inc, Applegate, WI.