Drug General Information (ID: DDI4TRN1JP)
Drug Name			Anakinra		Drug Info		Certolizumab pegol		Drug Info
Drug Type		Interferons				Monoclonal antibody
Therapeutic Class		Antiinflammatory Agents				Tnf Alfa Inhibitors

Mechanism of Anakinra-Certolizumab pegol Interaction (Severity Level: Major)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Anakinra				Certolizumab pegol
Mechanism		Immunosuppressive effects				Immunosuppressive effects
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Anakinra and Certolizumab pegol

Recommended Action
Management		Concomitant use of an IL-1 blocker and a TNF blocker is not recommended.

References
1	Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online.".
2	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
3	Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.