Drug General Information (ID: DDI4R9L83F)
Drug Name			Demeclocycline		Drug Info		Quinapril		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antihypertensive Agents
Structure

Mechanism of Demeclocycline-Quinapril Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Demeclocycline				Quinapril
Mechanism		Binds to polyvalent cations				Polyvalent cations (magnesium hydroxide excipient)
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Quinapril due to formation of complexes caused by Demeclocycline

Recommended Action
Management		The manufacturer does not make a specific recommendation, but generally the administration of tetracyclines and magnesium-containing products should be separated by two to four hours.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Nuzyra (omadacycline). Paratek Pharmaceuticals, Inc., Boston, MA.
3	Product Information. Seysara (sarecycline). Allergan Inc, Irvine, CA.