Details of Drug-Drug Interaction
| Drug General Information (ID: DDI3ZH4Q8G) | |||||||||
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| Drug Name | Methotrexate | Drug Info | Salicylic acid (sodium) | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antimetabolites | Antiinflammatory Agents | |||||||
| Structure | |||||||||
| Mechanism of Methotrexate-Salicylic acid (sodium) Interaction (Severity Level: Major) | |||||||||
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| Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Methotrexate | Salicylic acid (sodium) | |||||||
| Mechanism | Methotrexate | Competitive inhibition of renal tubular secretion of methotrexate | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Renal tubular secretion | ||||||||
| Factor Description | Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | If these agents must be used concomitantly, caution should be exercised and the patient should be monitored closely for signs and symptoms of bone marrow suppression and nephrotoxicity. Patients should be advised to report possible symptoms of toxicity including nausea, vomiting, diarrhea, stomatitis, sore throat, chills, fever, rash, unusual bruising or bleeding, jaundice, dark urine, swelling of the extremities, or shortness of breath to their physician. Patients should also be counseled to avoid any other over-the-counter salicylate products. | ||||||||