Drug General Information (ID: DDI3YMIPD6)
Drug Name			Voriconazole		Drug Info		Amphotericin B (liposomal)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antifungal Agents				Antifungal Agents
Structure

Mechanism of Voriconazole-Amphotericin B (liposomal) Interaction (Severity Level: Minor)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Voriconazole				Amphotericin B (liposomal)
Mechanism		Reduce therapeutic efficacy of Amphotericin B				Amphotericin B
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Voriconazole when combined with Amphotericin B (liposomal)

References
1	Saag MS, Powderly WG, Cloud GA, et al "Comparison of amphotericin B with fluconazole in the treatment of acute AIDS-associated cryptococcal meningitis." N Engl J Med 326 (1992): 83-9
2	Product Information. Fungizone (amphotericin B). Apothecon Inc, Plainsboro, NJ.
3	Product Information. Ambisome (amphotericin B liposomal) Nexstar Pharmaceuticals, San Dimas, CA.