Drug General Information (ID: DDI3WQJKXE)
Drug Name			Imipramine		Drug Info		Altretamine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidepressants				Antineoplastics
Structure

Mechanism of Imipramine-Altretamine Interaction (Severity Level: Moderate)
Additive hypotensive effects Click to Show/Hide Mechanism Graph
Drug Name		Imipramine				Altretamine
Mechanism 1		Antihypertensive agent				Hypotensive effects
Key Mechanism Factor 1
		Factor Name		Hypotensive effects
		Factor Description		Hypotension is a blood pressure reading below the prescribed limit (90/60 mmHg). Symptoms of hypotension may include: blurred or faded vision , dizziness or light-headedness, fainting , fatigue , difficulty concentrating, nausea.
Mechanism Description		Additive hypotensive effects by the combination of Imipramine and Altretamine
Mechanism 2		Hypotensive effects				Hypotensive effects
Key Mechanism Factor 2
		Factor Name		Hypotensive effects
		Factor Description		Hypotension is a blood pressure reading below the prescribed limit (90/60 mmHg). Symptoms of hypotension may include: blurred or faded vision , dizziness or light-headedness, fainting , fatigue , difficulty concentrating, nausea.
Mechanism Description		Additive hypotensive effects by the combination of Imipramine and Altretamine

Recommended Action
Management		Caution is advised if altretamine must be used with a MAOI or tricyclic antidepressant, particularly in elderly patients. All patients receiving the combination should be advised to avoid rising abruptly from a sitting or lying position and to contact their physician if they experience symptoms of hypotension such as dizziness, lightheadedness, or fainting.

References
1	Bruckner HW, Schleifer SJ "Orthostatic hypotension as a complication of hexamethylmelamine antidepressant interaction." Cancer Treat Rep 67 (1983): 516. [PMID: 6406063]
2	Product Information. Hexalen Capsules (altretamine). US Bioscience, West Conshohoken, PA.