Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDI3UZCIF5)
  Drug Name Minoxidil Drug Info Nefazodone Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antihypertensive Agents Antidepressants
  Structure

 Mechanism of Minoxidil-Nefazodone Interaction (Severity Level: Moderate)
     Additive hypotensive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Minoxidil Nefazodone
      Mechanism Antihypertensive agent
ATP-sensitive inward rectifier potassium channel  Inducer 		Potentiate the hypotensive effect of antihypertensive agents
      Key Mechanism Factor 1
Factor Name Inward rectifier potassium channel Structure Sequence
Protein Family Inward rectifier-type potassium channel (TC 1.A.2.1) family
Protein Function
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
    Click to Show/Hide
      Mechanism Description
  • Additive hypotensive effects by the combination of Minoxidil and Nefazodone 

Recommended Action
      Management Caution and close monitoring for altered efficacy and safety are recommended if patients receive nefazodone with agents that can produce significant hypotension such as antihypertensive agents or vasodilators. Patients should be made aware of the possible side effects (e.g., dizziness, lightheadedness, orthostasis) and be cautioned about driving, operating machinery, or performing other hazardous tasks.

References
1 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
2 Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
3 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]