Drug General Information (ID: DDI3ND0MT4)
Drug Name			Clonidine		Drug Info		Metyrosine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Antineoplastics
Structure

Mechanism of Clonidine-Metyrosine Interaction (Severity Level: Moderate)
Increased risk of atrioventricular block Click to Show/Hide Mechanism Graph
Drug Name		Clonidine				Metyrosine
Mechanism		Delay atrioventricular conduction				Delay atrioventricular conduction
Key Mechanism Factor 1
		Factor Name		Atrioventricular block
		Factor Description		Atrioventricular block is a type of cardiac conduction block that occurs when the electrical signal from the atria to the ventricles is impaired. In an Atrioventricular block, this electrical signal is either delayed or completely blocked. When the signal is completely blocked, the ventricles produce their own electrical signal to control the heart rate. The heart rate produced by the ventricles is much slower than that produced by the sinus node.
Mechanism Description		Increased risk of atrioventricular block by the combination of Clonidine and Metyrosine

Recommended Action
Management		Close clinical monitoring of hemodynamic response and tolerance is recommended if clonidine is prescribed with other sympatholytic drugs, and the dosage(s) adjusted as necessary.

References
1	Product Information. Catapres (clonidine). Boehringer-Ingelheim, Ridgefield, CT.