Drug General Information (ID: DDI3H2D6XJ)
Drug Name			Nitroglycerin		Drug Info		Biperiden		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasodilator Agents				Antiparkinson Agents
Structure

Mechanism of Nitroglycerin-Biperiden Interaction (Severity Level: Minor)
Affecting drug dissolution Click to Show/Hide Mechanism Graph
Drug Name		Nitroglycerin				Biperiden
Mechanism		Nitroglycerin				Decrease the dissolution of sublingual nitroglycerin
Key Mechanism Factor 1
		Factor Name		Salivary gland
		Factor Description		Sublingual administration requires the drug to be dissolved by saliva and then absorbed from the oral mucosa. The absorption of the drug may be decreased when saliva production is reduced.
Mechanism Description		Decreased dissolution of Nitroglycerin taken sublingually caused by Biperiden

References
1	Product Information. Nitrostat (nitroglycerin). Parke-Davis, Morris Plains, NJ.