Drug General Information (ID: DDI3F1Z4GK)
Drug Name			Lisdexamfetamine		Drug Info		Lactic acid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cns Stimulants				Topical Agents
Structure

Mechanism of Lisdexamfetamine-Lactic acid Interaction (Severity Level: Moderate)
Altered urine pH Click to Show/Hide Mechanism Graph
Drug Name		Lisdexamfetamine				Lactic acid
Mechanism		Urine pH sensitive				Urine alkalinizer
Key Mechanism Factor 1
		Factor Name		Urine pH
		Factor Description		The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion.
Mechanism Description		Altered elimination of Lisdexamfetamine caused by Lactic acid mediated altered urine pH

Recommended Action
Management		Urinary alkalinizers should generally not be used with amphetamines, particularly in an amphetamine overdose situation.

References
1	Anggard E, Jonsson LE, Hogmark AL, Gunne LM "Amphetamine metabolism in amphetamine psychosis." Clin Pharmacol Ther 14 (1973): 870-80. [PMID: 4729903]
2	Davis JM, Kopin IJ, Lemberger L, Axelrod J "Effects of urinary pH on amphetamine metabolism." Ann N Y Acad Sci 179 (1971): 493-501. [PMID: 5285389]
3	Wilkinson GR, Beckett AH "Absorption, metabolism and excretion of the ephedrines in man. I. The influence of urinary pH and urine volume output." J Pharmacol Exp Ther 162 (1968): 139-47. [PMID: 5656593]