Details of Drug Interaction | MecDDI

Drug General Information (ID: DDI3ETA27P)
Drug Name			Benzatropine		Drug Info		Metoclopramide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiparkinson Agents				Antiemetics
Structure

Mechanism of Benzatropine-Metoclopramide Interaction (Severity Level: Moderate)
Antagonize the effect of cholinergic agents Click to Show/Hide Mechanism Graph

Drug Name		Benzatropine				Metoclopramide
Mechanism		Anticholinergic effects Muscarinic acetylcholine receptor Antagonist				Cholinergic effects Dopamine receptor Antagonist
Key Mechanism Factor 1
		Factor Name		Muscarinic acetylcholine receptor M				Structure Sequence
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Click to Show/Hide
Key Mechanism Factor 2
		Factor Name		Dopamine receptor				Structure Sequence
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Click to Show/Hide
Mechanism Description		Antagonize the effect of Metoclopramide when combined with Benzatropine

Recommended Action
Management		Concomitant use of gastrointestinal prokinetic agents with anticholinergic agents should be avoided, if possible.

References
1	Product Information. Motilium (domperidone). Janssen-Ortho Inc, Toronto, ON.
2	Product Information. Reglan (metoclopramide). Wyeth-Ayerst Laboratories, Philadelphia, PA.
3	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]