Details of Drug-Drug Interaction
| Drug General Information (ID: DDI3EQYD71) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Ibutilide | Drug Info | Clarithromycin | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antiarrhythmic Agents | Antibiotics | |||||||
| Structure | |||||||||
| Mechanism of Ibutilide-Clarithromycin Interaction (Severity Level: Major) | |||||||||
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| Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Ibutilide | Clarithromycin | |||||||
| Mechanism | Prolong QT interval | Prolong QT interval | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | QT interval | ||||||||
| Factor Description | Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | The use of macrolide antibiotics in patients receiving class IA or class III antiarrhythmic agents antiarrhythmic agents should generally be avoided unless benefits are anticipated to outweigh the risks. Caution and clinical monitoring are recommended if these agents are prescribed together, especially to patients with underlying risk factors. Patients should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitations, irregular heartbeat, shortness of breath, or syncope. | ||||||||