Drug General Information (ID: DDI3CSN4JF)
Drug Name			Interferon alfa-2b		Drug Info		Tramadol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Analgesics
Structure

Mechanism of Interferon alfa-2b-Tramadol Interaction (Severity Level: Major)
Increased risk of lowers seizure threshold Click to Show/Hide Mechanism Graph
Drug Name		Interferon alfa-2b				Tramadol
Mechanism		Lower seizure threshold				Lower seizure threshold
Key Mechanism Factor 1
		Factor Name		Lowers seizure threshold
		Factor Description		The combination of medications that lower the seizure threshold is a factor that makes people with epilepsy more likely to have seizures. A seizure is a sudden, uncontrolled electrical disturbance in the brain that can cause changes in your behavior, movements or sensations, and level of consciousness.
Mechanism Description		Increased risk of lowers seizure threshold by the combination of Interferon alfa-2b and Tramadol

Recommended Action
Management		Caution is advised if tramadol is administered with any substance that can reduce the seizure threshold, particularly in the elderly and in patients with epilepsy, a history of seizures, or other risk factors for seizures (e.g., head trauma, brain tumor, metabolic disorders, alcohol and drug withdrawal, CNS infections).

References
1	Product Information. Ultram (tramadol). McNeil Pharmaceutical, Raritan, NJ.
2	Pisani F, Spina E, Oteri G "Antidepressant drugs and seizure susceptibility: from in vitro data to clinical practice." Epilepsia 40(Suppl 10) (1999): S48-56. [PMID: 10609604]
3	Rosenstein DL, Nelson JC, Jacobs SC "Seizures associated with antidepressants: a review." J Clin Psychiatry 54 (1993): 289-99. [PMID: 8253696]
4	Gardiner JS, Blough D, Drinkard CR, et al. "Tramadol and seizures: a surveillance study in a managed care population." Pharmacotherapy 20 (2000): 1423-31. [PMID: 11130214]