Drug General Information (ID: DDI308I472)
Drug Name			Clorazepic acid		Drug Info		Teduglutide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anxiolytics/Sedatives/Hypnotics				Gi Agents
Structure

Mechanism of Clorazepic acid-Teduglutide Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Clorazepic acid				Teduglutide
Mechanism		Absorption increased by teduglutide				Teduglutide
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Clorazepic acid caused by Teduglutide

Recommended Action
Management		Monitor patients receiving concomitant oral drugs requiring titration or with a narrow therapeutic index for adverse reactions due to potential increased absorption. The dose of the concomitant drug may need to be reduced.

References
1	Hukkinen SK, Varhe A, Olkkola KT, Neuvonen PJ "Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice." Clin Pharmacol Ther 58 (1995): 127-31. [PMID: 7648762]
2	Kupferschmidt HHT, Ha HR, Ziegler WH, Meier PJ, Krahenbuhl S "Interaction between grapefruit juice and midazolam in humans." Clin Pharmacol Ther 58 (1995): 20-8. [PMID: 7628179]
3	Product Information. Gattex (teduglutide). NPS Pharmaceuticals, Bedminster, NJ.