Drug General Information (ID: DDI2VGPKZ8)
Drug Name			Ranitidine (bismuth citrate)		Drug Info		Cefditoren		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiulcer Agents				Antibiotics
Structure

Mechanism of Ranitidine (bismuth citrate)-Cefditoren Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Ranitidine (bismuth citrate)				Cefditoren
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Cefditoren due to altered gastric pH caused by Ranitidine (bismuth citrate)

Recommended Action
Management		The manufacturer recommends that cefditoren pivoxil not be administered concomitantly with H2-receptor antagonists or other agents that reduce stomach acid.

References
1	Product Information. Spectracef (cefditoren). TAP Pharmaceuticals Inc, Deerfield, IL.