Drug General Information (ID: DDI2HL49M1)
Drug Name			Alemtuzumab		Drug Info		Ozanimod		Drug Info
Drug Type		Monoclonal antibody				Small molecule
Therapeutic Class		Antineoplastics				Selective Immunosuppressants

Mechanism of Alemtuzumab-Ozanimod Interaction (Severity Level: Major)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Alemtuzumab				Ozanimod
Mechanism		Immunosuppressive effects				Immunosuppressive effects
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Alemtuzumab and Ozanimod

Recommended Action
Management		According to the manufacturer, initiating treatment with ozanimod after treatment with alemtuzumab is not recommended. The safety and efficacy of ozanimod in combination with antineoplastic, immunosuppressive, or immune-modulating agents have not been evaluated.

References
1	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.