Drug General Information (ID: DDI2FH3EOD)
Drug Name			Ranitidine (bismuth citrate)		Drug Info		Ponatinib		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiulcer Agents				Multikinase Inhibitors
Structure

Mechanism of Ranitidine (bismuth citrate)-Ponatinib Interaction (Severity Level: Minor)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Ranitidine (bismuth citrate)				Ponatinib
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Ponatinib due to altered gastric pH caused by Ranitidine (bismuth citrate)

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.