Drug General Information (ID: DDI2DARXWG)
Drug Name			Acarbose		Drug Info		Pramlintide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidiabetic Agents				Antidiabetic Agents
Structure

Mechanism of Acarbose-Pramlintide Interaction (Severity Level: Moderate)
Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Drug Name		Acarbose				Pramlintide
Mechanism		Absorption is influenced by gastrointestinal motility				Decrease gastrointestinal motility
Key Mechanism Factor 1
		Factor Name		Gastrointestinal Motility
		Factor Description		Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
Mechanism Description		Altered absorption of Acarbose due to GI dynamics variation caused by Pramlintide

Recommended Action
Management		Due to its effect on gastric emptying, pramlintide therapy should not be considered for patients taking drugs that alter gastrointestinal motility or drugs that slow the intestinal absorption of nutrients.

References
1	Product Information. Symlin (pramlintide). Amphastar Pharmaceuticals Inc, South El Monte, CA.