Drug General Information (ID: DDI1MX9D23)
Drug Name			Isoflurane		Drug Info		Amiodarone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anesthetics				Antiarrhythmic Agents
Structure

Mechanism of Isoflurane-Amiodarone Interaction (Severity Level: Moderate)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Isoflurane				Amiodarone
Mechanism		Isoflurane				Increase the pharmacologic effects of isoflurane
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Isoflurane and Amiodarone

Recommended Action
Management		The patient's cardiorespiratory status should be closely monitored during surgery and until the effects of anesthesia have worn off.

References
1	Gallagher JD, Lieberman RW, Meranze J, Spielman SR, Ellison N "Amiodarone-induced complications during coronary artery surgery." Anesthesiology 55 (1981): 186-8. [PMID: 6973297]
2	Kerin NZ, Aragon E, Faitel K, Frumin H, Rubenfire M "Long-term efficacy and toxicity of high- and low-dose amiodarone regimens." J Clin Pharmacol 29 (1989): 418-23. [PMID: 2661600]
3	Liberman BA, Teasdale SJ "Anaesthesia and amiodarone." Can Anaesth Soc J 32 (1985): 629-38. [PMID: 4075214]