Drug General Information (ID: DDI1EYCXM7)
Drug Name			Phenytoin		Drug Info		Dopamine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticonvulsants				Cardiotonic Agents
Structure

Mechanism of Phenytoin-Dopamine Interaction (Severity Level: Moderate)
Additive hypotensive effects Click to Show/Hide Mechanism Graph
Drug Name		Phenytoin				Dopamine
Mechanism		Hydantoin derivative				Increase risk of hypotension combined with intravenous hydantoin derivative
Key Mechanism Factor 1
		Factor Name		Hypotensive effects
		Factor Description		Hypotension is a blood pressure reading below the prescribed limit (90/60 mmHg). Symptoms of hypotension may include: blurred or faded vision , dizziness or light-headedness, fainting , fatigue , difficulty concentrating, nausea.
Mechanism Description		Additive hypotensive effects by the combination of Phenytoin and Dopamine

Recommended Action
Management		Extreme caution and frequent blood pressure monitoring are recommended if concomitant use is necessary. alternative anticonvulsants may be considered.

References
1	Bivins BA, Rapp RP, Griffen WO Jr, Blouin R, Bustrack J "Dopamine-phenytoin interaction. A cause of hypotension in the critically ill." Arch Surg 113 (1978): 245-9. [PMID: 637689]
2	Cerner Multum, Inc. "Australian Product Information.".
3	Lorenzi M, Karam JH, Tsalikian E, Bohannon NV, Gerich JE, Forsham PH "Dopamine during alpha- or beta-adrenergic blockade in man. Hormonal, metabolic, and cardiovascular effects." J Clin Invest 63 (1979): 310-7. [PMID: 34629]