Drug General Information (ID: DDI1DLMKEC)
Drug Name			Ranitidine (bismuth citrate)		Drug Info		Nilotinib		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiulcer Agents				Antineoplastics
Structure

Mechanism of Ranitidine (bismuth citrate)-Nilotinib Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Ranitidine (bismuth citrate)				Nilotinib
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Nilotinib due to altered gastric pH caused by Ranitidine (bismuth citrate)

Recommended Action
Management		During concomitant use, it is recommended to administer the H2 antagonist 10 hours before and 2 hours after the dose of nilotinib.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.