Details of Drug-Drug Interaction
| Drug General Information (ID: DDI13DGVHM) | |||||||||
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| Drug Name | Dopamine | Drug Info | Metoclopramide | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Cardiotonic Agents | Antiemetics | |||||||
| Structure | |||||||||
| Mechanism of Dopamine-Metoclopramide Interaction (Severity Level: Minor) | |||||||||
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| Antagonize the effect of dopaminergic agents Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Dopamine | Metoclopramide | |||||||
| Mechanism |
Dopaminergic effects Dopamine D2 receptor Agonist |
Antidopaminergic effects Dopamine D2 receptor Antagonist |
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| Key Mechanism Factor 1 | |||||||||
| Factor Name | Dopamine D2 receptor |
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Structure
Sequence
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
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| Gene Name | DRD2 | ||||||||
| Uniprot ID | DRD2_HUMAN | ||||||||
| KEGG Pathway | hsa:1813 | ||||||||
| Protein Family | G-protein coupled receptor 1 family | ||||||||
| Protein Function |
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).
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| Mechanism Description |
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