Drug General Information (ID: DDI0X53ECA)
Drug Name			Leuprolide		Drug Info		Disopyramide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Antiarrhythmic Agents
Structure

Mechanism of Leuprolide-Disopyramide Interaction (Severity Level: Major)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Leuprolide				Disopyramide
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Leuprolide and Disopyramide

Recommended Action
Management		Coadministration of class IA or class III antiarrhythmic agents with other drugs that can prolong the QT interval should preferably be avoided unless benefits are anticipated to outweigh the risks. Caution and clinical monitoring are recommended if concomitant use is required. Patients should be advised to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope.

References
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6	Product Information. Cordarone (amiodarone). Wyeth-Ayerst Laboratories, Philadelphia, PA.
7	Product Information. Norpace (disopyramide). Searle, Skokie, IL.
8	Product Information. Procan SR (procainamide). Parke-Davis, Morris Plains, NJ.
9	Product Information. Quiniglute (quinidine). Berlex, Richmond, CA.
10	Product Information. Vascor (bepridil). McNeil Pharmaceutical, Raritan, NJ.
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