Drug General Information (ID: DDI0MSCEZR)
Drug Name			Acetylsalicylic acid		Drug Info		Lactic acid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Topical Agents
Structure

Mechanism of Acetylsalicylic acid-Lactic acid Interaction (Severity Level: Moderate)
Altered urine pH Click to Show/Hide Mechanism Graph
Drug Name		Acetylsalicylic acid				Lactic acid
Mechanism		Urine pH sensitive				Urine alkalinizer
Key Mechanism Factor 1
		Factor Name		Urine pH
		Factor Description		The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion.
Mechanism Description		Altered elimination of Acetylsalicylic acid caused by Lactic acid mediated altered urine pH

Recommended Action
Management		Patients treated chronically with urinary alkalinizers and large doses of salicylates (i.e. 3 g/day or more) should be monitored for potentially diminished or inadequate analgesic and anti-inflammatory effects, and the salicylate dosage adjusted if necessary.

References
1	Berg KJ "Acute effects of acetylsalicylic acid in patients with chronic renal insufficiency." Eur J Clin Pharmacol 11 (1977): 111-6. [PMID: 837963]
2	Brouwers JRBJ, Desmet PAGM "Pharmacokinetic-pharmacodynamic drug interactions with nonsteroidal anti-inflammatory drugs." Clin Pharmacokinet 27 (1994): 462-85. [PMID: 7882636]
3	Prescott LF, Balali-Mood M, Critchley JA, Johnstone AF, Proudfoot AT "Diuresis or urinary alkalinisation for salicylate poisoning?" Br Med J (Clin Res Ed) 285 (1982): 1383-6. [PMID: 6291695]