Drug General Information (ID: DDI0MLTY5K)
Drug Name			Zaleplon		Drug Info		Bupropion		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anxiolytics/Sedatives/Hypnotics				Antidepressants
Structure

Mechanism of Zaleplon-Bupropion Interaction (Severity Level: Moderate)
Antagonize the effect of antiepileptic agents Click to Show/Hide Mechanism Graph
Drug Name		Zaleplon				Bupropion
Mechanism		Antiepileptic agent				Lower seizure threshold
Key Mechanism Factor 1
		Factor Name		Antiepileptic agents
		Factor Description		The beneficial effects of antiepileptic drugs may be reduced, leading to an increase in seizure frequency or duration.
Mechanism Description		Antagonize the effect of Zaleplon when combined with Bupropion

Recommended Action
Management		Although sedatives may be prescribed to treat agitation, anxiety, and insomnia associated with bupropion use, patients should be alerted to the possibility of an increased risk of seizures during excessive exposure to these drugs. Patients should not attempt to alter the dosages or discontinue the medications on their own without consulting with their physician. The use of bupropion is contraindicated in patients undergoing abrupt discontinuation of sedatives.

References
1	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
2	James WA, Lippmann S "Bupropion: overview and prescribing guidelines in depression." South Med J 84 (1991): 222-4. [PMID: 1899294]
3	Product Information. Wellbutrin (bupropion). Glaxo Wellcome, Research Triangle Park, NC.