Drug General Information (ID: DDI0HD5L6X)
Drug Name			Lamotrigine		Drug Info		Orlistat		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticonvulsants				Antiobesity Agents
Structure

Mechanism of Lamotrigine-Orlistat Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Lamotrigine				Orlistat
Mechanism		Absorption possibly altered by orlistat				Orlistat
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Lamotrigine caused by Orlistat

Recommended Action
Management		Patients should be monitored for clinical and laboratory evidence of altered anticonvulsant efficacy. If this occurs, separation of the orlistat and anticonvulsant dosing time should be considered.

References
1	Bigham S, McGuigan C, MacDonald BK "Reduced absorption of lipophilic anti-epileptic medications when used concomitantly with the anti-obesity drug orlistat." Epilepsia 47 (2006): 2207. [PMID: 17201727]
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Xenical (orlistat). Roche Laboratories, Nutley, NJ.