Drug General Information (ID: DDI0FL43RM)
Drug Name			Digitoxin		Drug Info		Calcium gluconate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Minerals And Electrolytes
Structure

Mechanism of Digitoxin-Calcium gluconate Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Digitoxin				Calcium gluconate
Mechanism		Digitalis glycosides				Increase the arrhythmogenic effects of digitalis glycosides
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Digitoxin and Calcium gluconate

Recommended Action
Management		Intravenous calcium should preferably not be used in patients receiving digitalis glycosides, or it should be given slowly or in small amounts to avoid high serum calcium concentrations. Patients should be monitored for development of arrhythmias.

References
1	Product Information. Lanoxin (digoxin). Glaxo Wellcome, Research Triangle Park, NC.
2	Product Information. PhosLo (calcium acetate) Braintree, Braintree, MA.
3	Product Information. Calcium Gluconate (calcium gluconate). Fresenius Kabi USA, LLC, Lake Zurich, IL.