Drug General Information (ID: DDI04R3ACP)
Drug Name			Digitoxin		Drug Info		Parathyroid hormone		Drug Info
Drug Type		Small molecule				Hormones
Therapeutic Class		Antiarrhythmic Agents				Hormone Modulators

Mechanism of Digitoxin-Parathyroid hormone Interaction (Severity Level: Major)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Digitoxin				Parathyroid hormone
Mechanism		Potentiate the risk of digitalis toxicity				Digitalis glycosides
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Parathyroid hormone and Digitoxin

Recommended Action
Management		Serum calcium and digitalis levels should be closely monitored during parathyroid hormone therapy, and the digitalis dosage adjusted as necessary. Patients should be advised to seek medical attention if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeat.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
3	Product Information. Natpara (parathyroid hormone). NPS Pharmaceuticals, Bedminster, NJ.