Details of Drug

Details of Drug

 Drug General Information (ID: D1919)
  Drug Name
Varenicline
  Drug Type Small molecule
  Drug Synonymous
CP 526555; Champix (TN); Chantix (TN); Varenicline (INN); 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine; 7,8,9,10-tetrahydro-6h-6,10-methanoazepino[4,5-g]quinoxaline
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  Disease Class 6C4A: Nicotine use disorder
  Therapeutic Class Smoking Cessation Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C13H13N3
  InChI 1S/C13H13N3/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1/h1-2,4-5,8-9,14H,3,6-7H2
  InChIKey JQSHBVHOMNKWFT-UHFFFAOYSA-N
  Canonical SMILES C1C2CNCC1C3=CC4=NC=CN=C4C=C23
  External Link
Pubchem ID 170361
CAS Number CAS 249296-44-4
TTD ID D0LM4A
VARIDT ID DR00237

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
BM010  Transporter inhibition
  Relation Graph
 Full list of drugs interacting with Varenicline
      Affected cellular transport
   Transporter inhibition Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1383
 
Ranolazine
 
C24H33N3O4
 
56959 
Moderate    Inter Info   
[1], [2], [3]
D0181
 
Bictegravir
 
C21H18F3N3O5
 
90311989 
Moderate    Inter Info   
[4], [1], [5]
D0515
 
Dolutegravir
 
C20H19F2N3O5
 
54726191 
Moderate    Inter Info   
[6], [7]
D1681
 
Vandetanib
 
C22H24BrFN4O2
 
3081361 
Moderate    Inter Info   
[1], [8], [9]
D0337
 
Cimetidine
 
C10H16N6S
 
2756 
Minor    Inter Info   
[3], [10]
D0890
 
Lamotrigine
 
C9H7Cl2N5
 
3878 
Minor    Inter Info   
[1], [11], [12]
References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
3 FDA. U.S. Food and Drug Administration "Drug Safety Communications: FDA updates label for stop smoking drug Chantix (varenicline) to include potential alcohol interaction, rare risk of seizures, and studies of side effects on mood, behavior, and thinking. Safety announcement." .
4 Cerner Multum, Inc. "Australian Product Information.".
5 Product Information. Biktarvy (bictegravir/emtricitabine/tenofovir). Gilead Sciences, Foster City, CA.
6 Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
7 Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
8 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
9 Product Information. Vandetanib (vandetanib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
10 Product Information. Chantix (varenicline). Pfizer U.S. Pharmaceuticals Group, New York, NY.
11 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
12 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]