Details of Drug | MecDDI

Drug General Information (ID: D1884)
Drug Name		Sapropterin
Drug Type		Small molecule
Drug Synonymous		Sapropterin\|tetrahydrobiopterin\|62989-33-7\|R-THBP\|6R-BH4\|Sapropterina\|Sapropterinum\|Dapropterin\|(6R)-L-erythro-tetrahydrobiopterin\|5,6,7,8-tetrahydrobiopterin\|Kuvan\|Sapropterin [INN]\|6R-5,6,7,8-Tetrahydrobiopterin\|6R-L-5,6,7,8-Tetrahydrobiopterin\|L-erythro-tetrahydrobiopterin\|Sapropterin (INN)\|UNII-EGX657432I\|tetrahydro-l-biopterin\|(6R)-5,6,7,8-Tetrahydrobiopterin\|2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-pteridinone\|(-)-(6R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3H)-pteridinone\|(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one\|CHEBI:59560\|(6R)-L-erythro-5,6,7,8-Tetrahydrobiopterin\|tetra-H-biopterin\|(6R)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN\|EGX657432I\|tetra-hydro-biopterin\|(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-1H-pteridin-4-one\|17528-72-2\|(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one\|(R)-2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(1H)-one\|5,6,7,8-tetra-H-biopterin\|BH4\|(6R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(1H)-one\|4(1H)-Pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-, (6r)-\|Sapropterin [MI]\|Sapropterin [VANDF]\|(6R)-Tetrahydrobiopterin\|Sapropterin [EMA EPAR]\|Sapropterinum [INN-Latin]\|Sapropterina [INN-Spanish]\|Tetrahydrobiopterin [WHO-DD]\|5,6,7,8-Tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone\|(1R,2S)-(2-Amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)-1,2-propandiol\|L-erythro-2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3H)-pteridinon\|5,6,7,8-erythro-tetrahydrobiopterin\|DAPROTERIN\|6R-Tetrahydrobiopterin\|tetrahydrobiopterin (THB)\|bmse000911\|THB\|SCHEMBL258544\|GTPL5276\|CHEMBL1201774\|DTXSID1041138\|BCBcMAP01_000204\|2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one\|Biopterin, 5,6,7,8-tetrahydro-\|BCP03735\|EX-A2877\|BDBM50373697\|ZINC13585233\|DB00360\|(6R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone\|4(1H)-Pteridinone, (6R)-2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-\|SMP1_000285\|NCGC00485328-01\|(6r)-erythro-5,6,7,8-tet-rahydrobiopterin\|(6R)-5,6,7,8-Tetrahydro-L-biopterin 2HCl\|C00272\|C16118\|D08505\|W-203341\|W-203533\|69081654-1FB6-4B89-B9B9-823C9887EE36\|2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone\|2-Amino-6R-(1R,2S-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone\|(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-3,4,5,6,7,8-hexahydropteridin-4-one\|(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-3H-pteridin-4-one\|(R)-2-Amino-6-((1R,2S)-1,2-dihydroxy-propyl)-5,6,7,8-tetrahydro-1H-pteridin-4-one\|4(1H)-Pteridinone,2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro\|2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-5,6,7,8-Tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone\|27070-47-9 Click to Show/Hide
Therapeutic Class		Metabolic Agents
Structure
Structure		3D Structure				2D Structure
Formula		C9H15N5O3
InChI		1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)/t3-,4+,6-/m0/s1
InChIKey		FNKQXYHWGSIFBK-RPDRRWSUSA-N
Canonical SMILES		CC(C(C1CNC2=C(N1)C(=O)NC(=N2)N)O)O
External Link
		Pubchem ID		135398654
		CAS Number		CAS 62989-33-7
		CHEBI ID		CHEBI:59560
		TTD ID		D0F9XO
		INTEDE ID		DR2017

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM007 Pharmacodynamic antagonistic effects BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Sapropterin
Pharmacodynamic antagonistic effects
					Attenuated pharmacological effects (Unspecific)																																																																Drug Num: 7
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D1366															Pyrimethamine															C12H13ClN4															4993															Moderate															Inter Info													[1], [2]
D1025															Methotrexate															C20H22N8O5															126941															Moderate															Inter Info													[1], [2]
D1241															Pemetrexed															C20H21N5O6															135410875															Moderate															Inter Info													[1], [2]
D1323															Pralatrexate															C23H23N7O5															148121															Moderate															Inter Info													[1], [2]
D1350															Proguanil															C11H16ClN5															6178111															Moderate															Inter Info													[1], [2]
D1645															Trimethoprim															C14H18N4O3															5578															Moderate															Inter Info													[1], [2]
D1646															Trimetrexate															C19H23N5O3															5583															Moderate															Inter Info													[1], [2]

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Product Information. Kuvan (sapropterin). BioMarin Pharmaceutical Inc, Novato, CA.