Details of Drug

Details of Drug

 Drug General Information (ID: D1848)
  Drug Name
Minoxidil (topical)
  Drug Type Small molecule
  Drug Synonymous
Alopexil; Alostil; Loniten; Lonolox; Minodyl; Minossidile; Minoxidilum; Minoxigaine; Minoximen; Neoxidil; Normoxidil; Pierminox; Prexidil; Regaine; RiUP; Rogaine; Theroxidil; Tricoxidil; Trocoxidil; MINOXIDIL EXTRA STRENGTH FOR MEN; Men s Rogaine Foam; Mens Rogaine Foam; Minossidile [Italian]; Minoxidil Pfizer Brand; PfizerBrand of Minoxidil; Rogaine Extra Strength for Men; Rogaine for Men; Rogaine for Women; M 4145; M1389; U 10858; Apo-Gain; Gen-Minoxidil; Loniten (TN); MINOXIDIL (FOR MEN); MINOXIDIL (FOR WOMEN); MINOXIDIL EXTRA STRENGTH (FOR MEN); Men's Rogaine; Minoxidilum [INN-Latin]; ROGAINE (FOR MEN); ROGAINE (FOR WOMEN); ROGAINE EXTRA STRENGTH (FOR MEN); Regaine (TN); Riup (TN); Rogaine (TN); TM-160; U-10858; Minoxidil (USP/INN); Minoxidil [USAN:BAN:INN]; U-10,858; Rogaine, Regaine, Avacor and Mintop, Minoxidil; Pyrimidine, 2,4-diamino-6-piperidino-, 3-oxide; 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine; 2,4-Diamino-6-piperidinilpirimidina-3-ossido; 2,4-Diamino-6-piperidinilpirimidina-3-ossido [Italian]; 2,4-Diamino-6-piperidino-pyrimidine-3-oxide; 2,4-Diamino-6-piperidinopyrimidine 3-N-oxide; 2,4-Diamino-6-piperidinopyrimidine 3-oxide; 2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide; 2,6-Diamino-4-piperidinopyrimidin-1-oxid; 3-hydroxy-2-imino-6-(1-piperidyl)pyrimidin-4-amine; 3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine; 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide; 6-(piperidin-1-yl)pyrimidine-2,4-diamine 3-oxide; 6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine; 6-Piperidino-2,4-diaminopyrimidine 3-oxide; 6-[1-Piperidinyl]pyrimidine-2,4-diamine 3 oxide
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  Disease Class BA00-BA04: Hypertension
  Therapeutic Class Antihypertensive Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C9H15N5O
  InChI 1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
  InChIKey ZIMGGGWCDYVHOY-UHFFFAOYSA-N
  Canonical SMILES C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O
  External Link
Pubchem ID 4201
CAS Number CAS 38304-91-5
CHEBI ID CHEBI:6942
TTD ID D0Y2CJ
INTEDE ID DR1095

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM042  Additive hypotensive effects
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Minoxidil (topical)
      Pharmacodynamic additive effects
   Additive hypotensive effects Drug Num:  31
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0036
 
Alfuzosin
 
C19H27N5O4
 
2092 
Moderate    Inter Info   
[1], [2]
D0743
 
Guanadrel
 
C10H19N3O2
 
38521 
Moderate    Inter Info   
[1], [2]
D0046
 
Alprostadil
 
C20H34O5
 
5280723 
Moderate    Inter Info   
[1], [2]
D0053
 
Ambrisentan
 
C22H22N2O4
 
6918493 
Moderate    Inter Info   
[1], [2]
D0083
 
Amyl Nitrite
 
C5H11NO2
 
10026 
Moderate    Inter Info   
[1], [2]
D0128
 
Avanafil
 
C23H26ClN7O3
 
9869929 
Moderate    Inter Info   
[1], [2]
D0194
 
Bosentan
 
C27H29N5O6S
 
104865 
Moderate    Inter Info   
[1], [2]
D0396
 
Cyclandelate
 
C17H24O3
 
2893 
Moderate    Inter Info   
[1], [2]
D0444
 
Deserpidine
 
C32H38N2O8
 
8550 
Moderate    Inter Info   
[1], [2]
D0524
 
Doxazosin
 
C23H25N5O5
 
3157 
Moderate    Inter Info   
[1], [2]
D0586
 
Epoprostenol
 
C20H32O5
 
5282411 
Moderate    Inter Info   
[1], [2]
D0744
 
Guanethidine
 
C10H22N4
 
3518 
Moderate    Inter Info   
[1], [2]
D0792
 
Iloprost
 
C22H32O4
 
5311181 
Moderate    Inter Info   
[1], [2]
D0860
 
Isosorbide
 
C6H10O4
 
12597 
Moderate    Inter Info   
[1], [2]
D0861
 
Isosorbide dinitrate
 
C6H8N2O8
 
6883 
Moderate    Inter Info   
[1], [2]
D0862
 
Isosorbide mononitrate
 
C6H9NO6
 
27661 
Moderate    Inter Info   
[1], [2]
D0864
 
Isoxsuprine
 
C18H23NO3
 
3783 
Moderate    Inter Info   
[1], [2]
D0983
 
Mecamylamine
 
C11H21N
 
4032 
Moderate    Inter Info   
[1], [2]
D1125
 
Nesiritide
 
C143H244N50O42S4
 
53325981 
Moderate    Inter Info   
[1], [2]
D1146
 
Nitroglycerin
 
C3H5N3O9
 
4510 
Moderate    Inter Info   
[1], [2]
D1223
 
Papaverine
 
C20H21NO4
 
4680 
Moderate    Inter Info   
[1], [2]
D1331
 
Prazosin
 
C19H21N5O4
 
4893 
Moderate    Inter Info   
[1], [2]
D1457
 
Selexipag
 
C26H32N4O4S
 
9913767 
Moderate    Inter Info   
[1], [2]
D1466
 
Silodosin
 
C25H32F3N3O4
 
5312125 
Moderate    Inter Info   
[1], [2]
D1527
 
Tadalafil
 
C22H19N3O4
 
110635 
Moderate    Inter Info   
[1], [2]
D1534
 
Tamsulosin
 
C20H28N2O5S
 
129211 
Moderate    Inter Info   
[1], [2]
D1552
 
Terazosin
 
C19H25N5O4
 
5401 
Moderate    Inter Info   
[1], [2]
D1625
 
Treprostinil
 
C23H34O5
 
6918140 
Moderate    Inter Info   
[1], [2]
D1682
 
Vardenafil
 
C23H32N6O4S
 
135400189 
Moderate    Inter Info   
[1], [2]
D1393
 
Reserpine
 
C33H40N2O9
 
5770 
Moderate    Inter Info   
[1], [2]
D1465
 
Sildenafil
 
C22H30N6O4S
 
135398744 
Moderate    Inter Info   
[1], [2]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1691
 
Verteporfin
 
C82H84N8O16
 
11980904 
Moderate    Inter Info   
[3], [4]
References
1 Leenen FH, Smith DL, Unger WP "Topical minoxidil: cardiac effects in bald men." Br J Clin Pharmacol 26 (1988): 481-5. [PMID: 3191000]
2 Product Information. Rogaine (minoxidil topical). Johnson and Johnson/McNeil Consumer, Fort Washington, PA.
3 Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
4 Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.